Relationship between humans and nature. There is a remarkable harmony between the environment and human beings. Humans, by themselves, cannot synthesize leucine and must get it from their enviroment. Plants and microorganisms, however, can synthesize leucine, which can then be passed down to animals and humans through food chains. Because of their relationship with a vast array of plants and animals, humans can get the necessary leucine, as can animals.
Harmony in the universe. The precision and complex coordination in the universe is revealed in leucine's role in proteins. Similar to isoleucine and valine, leucine's structure makes it important for the correct folding of proteins. The functionality of a protein is dependent upon its ability to fold into a precise three-dimensional shape.
Personal responsibility. Individuals have a personal responsibility to eat foods that are good for their "temple" (body). Thus, one needs to exhibit discipline. In the case of leucine, it is an "essential amino acid," meaning one must obtain it from one's diet—it cannot be synthesized from other materials. Thus, it is important to include in one's diet those foods that have sufficient leucine. In the case of the metabolic deficiency disease, maple syrup urine disease, caused by a deficiency of the enzyme branched chain α-keto acid dehydrogenase (BCKDH), the importance of diet is especially emphasized. In this disorder, one gets a buildup of the branched-chain amino acids valine, leucine, and isoleucine in the blood and urine. Thus, one's diet must allow one to get the minimal levels of leucine (and isoleucine and valine) without too much to cause the disease. This diet must be adhered to strictly and permanently. However, with proper treatment those afflicted are able to live healthy, normal lives and not suffer the severe neurological damage that characterizes the untreated disease.
Unification Aspects is designed to relate the subject of this article to Unification Thought and to aid teachers and researchers who wish to further pursue these topics from a unification perspective.