Lung
The lung is the essential respiratory organ in air-breathing vertebrates. Its principal function is to transport oxygen from the atmosphere into the bloodstream and to excrete carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is essential for the function of these organisms: oxygen powers the production of chemical energy (in the form of ATP) via aerobic respiration, while the carbon dioxide by-product of cellular respiration is toxic at high concentrations and must be removed from the system.
A bit of an overview/description of the lung: spongy; they are typically designed to maximize surface area. Maybe something general about moisture: The environment of the lung is very moist, which makes it hospitable for bacteria. Many respiratory illnesses are the result of bacterial or viral infection of the lungs.
The anatomy of the lung and respiratory mechanisms are adapted to the particular needs of the organism, though many features are shared. Air enters through the trachea (commonly referred to as the windpipe) and subdivides into smaller airways called bronchi. In most air-breathing vertebrates, the bronchi further subdivide into finer pathways of branching airways, until they culminate in specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli, where gas exchange occurs.
In birds, however, the bronchi do not have dead ends, so that air can flow completely throughout the lungs. In addition, the lungs are complimented by air sacs, which allow for a unidirectional flow of air that enables birds to pick up a greater concentration of oxygen from inhaled air. The anatomy of their respiratory system thus equips birds to fly at altitudes with low oxygen content and to sustain extremely high levels of activity for longer periods than possible for mammals.
The evolution of lungs played a crucial role in the development of complex organisms. In small organisms, such as single-celled bacteria, gas exchange can take place entirely by simple diffusion. In larger organisms, however, only a small proportion of cells are close enough to the surface for oxygen from the atmosphere to enter through diffusion. Thus, two major adaptations made it possible for organisms to attain great multicellularity: an efficient circulatory system that conveyed gases to and from the deepest tissues in the body, and a large, internalized respiratory system that centralized the task of obtaining oxygen from the atmosphere and bringing it into the body, whence it could rapidly be distributed to any part of the circulatory system.
Overview of the lung’s structure and function
In air-breathing vertebrates, respiration occurs in a series of steps. Air is brought into the animal via the airways — in reptiles, birds, and mammals this often consists of the nose; the pharynx; the larynx; the trachea (also called the windpipe); the bronchi and bronchioles; and the terminal branches of the respiratory tree.
The drawing and expulsion of air is driven by muscular action; in early tetrapods, air was driven into the lungs by the pharyngeal muscles, whereas in reptiles, birds and mammals a more complicated musculoskeletal system is used.
Lungs are to a certain extent 'overbuilt' and have a tremendous reserve volume as compared to the oxygen exchange requirements when at rest (something like 1/20 of capacity is used). This is the reason that individuals can smoke for years without having a noticeable decrease in lung function while still or moving slowly; in situations like these only a small portion of the lungs are actually perfused with blood for gas exchange. As oxygen requirements increase due to exercise, a greater volume of the lungs is perfused (supplied with arterial blood), allowing the body to match its CO2/O2 exchange requirements.
Mammalian lungs
Anatomy
The lungs of mammals have a spongy texture and are honeycombed with epithelium (a thin layer of tightly packed cells), a structure that maximizes the surface area for gas exchange.
Mammalian lungs are located in two cavities on either side of the heart. Though similar in appearance, the two lungs are not identical. Both are separated into lobes, with three lobes on the right and two on the left. The lobes are further divided into lobules, hexagonal divisions that are the smallest subdivision visible to the naked eye.
Two main bronchi (produced by the bifurcation of the trachea) enter the roots of the lungs. The bronchi continue to divide within the lung, and after multiple divisions, give rise to bronchioles. The bronchial tree continues branching until it reaches the level of terminal bronchioles, which lead to alveolar sacs. The latter are made up of clusters of alveoli, like individual grapes within a bunch. The individual alveoli are tightly wrapped in blood vessels, and it is here that gas exchange actually occurs. Deoxygenated blood from the heart is pumped through the pulmonary artery to the lungs, where oxygen diffuses into blood and is exchanged for carbon dioxide in the hemoglobin of the erythrocytes. The oxygen-rich blood returns to the heart via the pulmonary veins to be pumped back into systemic circulation.
Mechanism of respiration
Breathing is largely driven by the muscular diaphragm at the bottom of the thorax. Contraction of the diaphragm pulls the bottom of the cavity in which the lung is enclosed downward. Air enters through the oral and nasal cavities; it flows through the larynx and into the trachea, which branches out into bronchi. Relaxation of the diaphragm has the opposite effect, passively recoiling during normal breathing. During exercise, the diaphragm contracts, forcing the air out more quickly and forcefully. The rib cage is also able to expand and contract to some degree, through the action of other respiratory and accessory respiratory muscles. As a result, air is sucked into or expelled out of the lungs, always moving down its pressure gradient. This type of lung is known as a bellows lung as it resembles a blacksmith's bellows (explain – tidal mechanism of air flow?). . Because mammalian lungs are dead-ends, ventilation must be tidal: air comes in and flows out by the same route.
Avian lungs
Anatomy
In contrast to mammalian lungs, avian lungs do not contain alveoli; instead, they contain millions of tiny passages known as parabronchi. Air flows through the honeycombed walls of the parabronchi and into air capillaries, where oxygen and carbon dioxide are traded with cross-flowing blood capillaries by diffusion, a process of crosscurrent exchange. In addition to the lungs, birds possess two sets of air sacs, one towards the front, and a second towards the back.
Mechanism of respiration
Two cycles of inhalation/exhalation required for the air to travel through the bird’s respiratory tract. A bird's lungs do not store air in either of the sacs between respiration cycles; air moves continuously from the posterior to anterior air sacs throughout respiration. This type of lung construction is called a circulatory lung, and is distinct from the bellows lung possessed by most other animals:
- At the first inhalation, air travels backwards into the rear (caudal) sac, and a small portion travels forward past the parabronchi and oxygenating the blood into the cranial air sac.
- During exhalation, this breath of air flows from the posterior sacs into the lungs. On exhalation, deoxygenated air held in the cranial air sack is exhaled, and the still-oxygenated air stored in the caudal sack moves over the parabronchi and is exhaled, with some remaining in the cranial sac.
- During the next inhalation, the breath flows from the lungs to the anterior sacs.
- During the next exhalation, the breath of air is expelled.
The complex system of air sacs ensures that the airflow through the avian lung always travels in the same direction - posterior to anterior. This mechanism works differently than the mammalian system, in which the direction of airflow in the lung is tidal, reversing between inhalation and exhalation. By utilizing a unidirectional flow of air, avian lungs are able to extract a greater concentration of oxygen from inhaled air. Birds are thus equipped to fly at altitudes at which mammals would succumb to hypoxia (in which an inadequate amount of oxygen reaches the tissues). Their respiratory system also allows them to sustain a higher metabolic rate than that of a mammal with an equivalent weight.
Reptilian lungs
Reptilian lungs are typically ventilated by a combination of expansion and contraction of the ribs via axial muscles and buccal pumping. Crocodilians, an order of reptiles that are the closest living relatives of birds, also rely on the hepatic piston method, in which the liver is pulled back by a muscle anchored to the pubic bone (part of the pelvis), which in turn pulls the bottom of the lungs backward, expanding them.
Amphibian lungs
The lungs of most frogs and other amphibians are simple balloon-like structures, with gas exchange limited to the outer surface area of the lung. Although it is not an efficient arrangement, amphibians have low metabolic demands and also frequently supplement their oxygen supply by diffusion across the moist outer skin of their bodies.
Invertebrate "lungs"
The term "lung" is sometimes used to describ structures in some invertebrates that serve a similar respiratory purpose, but are not evolutionarily related to vertebrate lungs. Some arachnids use structures called "book lungs" for atmospheric gas exchange. The Coconut crab uses structures called branchiostegal lungs to breathe air must hold its breath underwater. The Pulmonata are an order of snails and slugs that have developed "lungs."
Non-respiratory functions
In addition to respiratory functions such as gas exchange and regulation of hydrogen ion concentration, the lungs may also play the following roles, which help to ensure proper biological function:
- Lungs serve as a physical layer of soft, shock-absorbent protection for the heart, which the lungs flank and nearly enclose.
- Water, alcohol, and drugs can be absorbed and excreted via the lungs.
- Fat in the bloodstream can be removed and stored in the alveolar cells.
- Lungs can store glycogen (the storage form of glucose]] and metabolize it, aiding the liver in its regulation of blood glucose levels.
- Lungs can filter out small blood clots formed in veins.
Evolutionary origins of lungs
The lungs of today's terrestrial vertebrates and the gas bladders of today's fish have evolved from simple sacs (outpocketings) of the esophagus (part of the digestive tract), which allowed the ancestral organism to gulp air under oxygen-poor conditions. Thus, the lungs of vertebrates are homologous to the gas bladders of fish (but not to their gills): i.e., they signal descent from a common ancestor.
Further reading
- The Franklin Institute. 2007. The Respiratory System. Retrieved July 19, 2007.
- Hopley, L. and J. van Schalkwyk. 2006. Lung Function Fundamentals. Retrieved July 19, 2007.
- Johnson, D.R. date? Introductory anatomy, respiratory system University of Leeds. Retrieved July 19, 2007.
ReferencesISBN links support NWE through referral fees
- Purves, W., D. Sadava, G. Orians, and C. Heller. 2004. Life: The Science of Biology, 7th edition. Sunderland, M.A.: Sinauer.
- Ritchison, G. date? Avian lungs and respiration. Ornithology course page. Eastern Kentucky University. Retrieved July 19, 2007.
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