From New World Encyclopedia

β-Carotene represented by a 3-dimensional stick diagram.

The term carotene refers to a class of related organic compounds with the formula C40H56. Carotenes exist in several isomers that have the same formula but different molecular structures. These yellow-orange pigments are synthesized by plants and photosynthetic bacteria, while animals must obtain them as a nutrient from the diet.

Along with chlorophyll and other pigments found in specialized chloroplasts, carotenes absorb energy from sunlight to be used in photosynthesis, a process in which solar energy is converted into potential chemical energy in the form of glucose. The carotene molecules transmit the absorbed light energy to chlorophyll to be funneled into the reactions of photosynthesis.

Carotene is also the precursor to vitamin A in animals. Although several carotenes are capable of producing vitamin A, the most active form is the isomer beta-carotene. Vitamin A plays an important role in vision.

Carotene is a pigment responsible for the orange color of carrots.

In all living organisms, carotenes function as antioxidants, which work by making themselves available for energetically favorable oxidation (donation of electrons). As such, they can be useful for curbing the excesses of damaging free radicals, which contain an unpaired electron and thus are highly reactive. Free radicals oxidize the molecules that make up cell membranes and other vital tissues, altering their function. Antioxidants like the carotenes react readily with these free radicals before they can react with other compounds in the organism.

Carotenes contribute a yellow or orange pigmentation to fruits such as apricots, root vegetables like carrots and sweet potatoes, and flowers such as dandelions and marigolds. The leafy greens broccoli and spinach are also good dietary sources, though the presence of carotene is visually masked by the green of chlorophyll molecules. Carotenes also give color to milk fat and egg yolks, and contribute to the ornamental hue of lobster shells.

Carotenes (and their parent group, the carotenoids) are examples of ubiquitous compounds called isoprenoids, which may be thought of as the “sensual molecules” that contribute diverse colors and fragrances to the natural world (Stryer 1995). They attest to nature’s ability to use simple building blocks to create an array of compounds. The carotenes and other isoprenoids also demonstrate the functional role of beauty in the perpetuation of life.

Chemical structure and properties

Chemically, carotene is a terpene, one of a large class of hydrocarbons derived biosynthetically from units of isoprene, which has the molecular formula C5H8. Carotenes are synthesized from eight units of isoprene, which may be considered one of nature's preferred building blocks.

Carotene naturally occurs in a variety of isomeric forms, which are designated by characters from the Greek alphabet. Although alpha-carotene (α-carotene) and beta-carotene (β-carotene) are the two primary forms of carotene, gamma, delta, and epsilon (γ, δ and ε-carotene) configurations also exist.


The two primary isomers of carotene, α-carotene and β-carotene, differ in the position of double bonds in the cyclic group at the end of the molecule.

Carotenes absorb light because they contain extended networks of alternating single and double bonds (i.e., they are polyenes). These double carbon-carbon bonds interact in a process known as conjugation, which results in an overall lower energy state. Normally, carbon-carbon double bonds that are not conjugated or only partially conjugated absorb light in the ultraviolet region of a spectrum; however, the absorption energy state of polyenes with numerous conjugated double bonds can be lowered such that they enter the visible region of the spectrum, resulting in compounds that are colored yellow and orange.


In plants and photosynthetic bacteria, carotenes are synthesized from isopentenyl pyrophosphate, the basic 5-carbon building block. Their 40-carbon skeletons are built by the successive addition of five-carbon units to form a 20-carbon intermediate, which is then joined tail-to-tail with a second 20-carbon molecule. Phytoene, a 40-carbon molecule, condenses to yield lycopene. Cyclization of both ends of lycopene produces the characteristic ring structure of beta-carotene.

Functions in living organisms

Carotenes are light-harvesting pigments in photosynthesis

Carotenoids are present in plants and photosynthetic bacteria. They absorb light at other wavelengths than those absorbed by the two types of chlorophyll pigments (called chlorophyll a and b), thus extending the range of light that can be absorbed from sunlight and used for photosynthesis. Carotenes and other light-absorbing pigments present in the antennas of chloroplasts funnel the energy of absorbed light to the two chlorophyll molecules at the reaction center, where high-energy molecules such as ATP and NADPH are ultimately generated.

Beta-carotene is a precursor to vitamin A in animals

Beta-carotene can be stored in the liver and converted to vitamin A as needed, thus making it a provitamin (i.e., a precursor to the vitamin). Vitamin A (also known as retinol) is a fat-soluble alcohol that plays a crucial role in vision; it is converted to a component of the light-sensitive pigment rodopsin present in the retina of the eye.

Carotenes serve as antioxidants

Along with vitamins C and E, and a group of related compounds called coenzyme Q, carotones also act as antioxidants in a variety of organisms. They shelter prokaryotes from the deleterious effects of light, and protect vital cell functions in plants against the destructive effects of ultraviolet light, acting in a sense like the plant’s sunscreen.

The color of carotene plays a role in reproduction

A wide range of carotenoids and other colorful compounds abound in the plant kingdom. The benefits for the plant in expending resources to produce these compounds are visible in their role in attracting insects for pollination and luring animals for seed distribution.

Carotenoids are also common in animals, which cannot synthesize these molecules and must obtain them through the diet; in animals, they often function as ornamental features. For example, the red coloring of lobsters’ shells is created by carotene pigments. It has been proposed that carotenoids are used in ornamental traits because, given their physiological and chemical properties, they can be taken as honest indicators of individual health; hence, they are useful signposts when selecting potential mates.


Dietary sources

Beta-carotene is the most common isomer and can be found in a variety of plants, including certain flowers (e.g., dandelions and marigolds), fruits (e.g., pumpkin, apricot, and cantaloupe), root vegetables (e.g. carrots and sweet potatoes), and leafy greens (e.g., broccoli and spinach). β-carotene is also responsible for the coloration of yellow-orange bell peppers.

Pigmentation caused by carotenes is also manifested in certain animals and animal products, such as egg yolks, the shells of lobsters, and the yellow-colored milk of Guernsey cows, noted for its high beta-carotene content.

Carotene supplements

Beta-carotene was isolated from carrots early in the twentieth century, and first synthesized by scientists around 1950. Today, most of the world's synthetic supply of carotene comes from a manufacturing complex located in Freeport, Texas and owned by DSM. In Spain, Vitatene produces natural beta-carotene from Blakeslea trispora, a plant pathogen. In Australia, organic beta-carotene is produced by Aquacarotene Limited from dried marine algae (Dunaliella salina) grown in harvesting ponds.

Beta-carotene and human health


The RDA (Recommended Daily Allowance) for beta-carotene is rather low: 1000 mg for males and 800 mg for females, with slightly higher amounts for pregnant or lactating women. Although touted as a beneficial nutrient, too much vitamin A can actually be harmful to the body. Carotenemia or hypercarotenemia refers to a disorder caused by excess carotene. Unlike excess vitamin A, carotene is non-toxic. Although hypercarotenemia is not particularly dangerous, it can lead to a yellow-orange discoloration of the skin (carotenodermia), most often appearing around the palms of the hands and the soles of the feet. It is most commonly associated with over-consumption of carrots, but it also can be a medical sign of more serious conditions such as diabetes mellitus, anorexia nervosa, and porphyria.

Beta-carotene and cancer

Carotenoids are efficient free-radical scavengers that enhance the vertebrate immune system. Consequently, epidemiological studies have shown that people with high beta-carotene intake and high plasma levels of beta-carotene have a significantly reduced risk of lung cancer.

However, studies of supplementation with large doses of synthetic beta-carotene in smokers or those with asbestos exposure have shown an increase in cancer risk. One explanation for this finding is that excessive beta-carotene leads to breakdown products that reduce plasma vitamin A and worsen the lung cell proliferation induced by smoke (Omenn 1996; American Cancer Society 2000; Bjelavokic et al. 2007).

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External links

All links retrieved November 28, 2023.


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