Addison's disease

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Addison's disease is the hyposecretion of all adrenal steroid hormones. It usually follows the autoimmune destruction (immune system creates antibodies against the body's own tissues) of the adrenal cortex. Inherited disorders in which defective enzymes for adrenal steroid production are produced are often marked by excess androgen secretion. This is because substrates that cannot be made into cortisol or aldosterone are converted to androgens.

Hyposecretion pathologies are far less common than Cushing's syndrome.