Difference between revisions of "Phenotype" - New World Encyclopedia

From New World Encyclopedia
Line 2: Line 2:
 
[[Image:Coquina variation3.jpg|thumb|right|260px|Individuals in the [[Mollusca|mollusk]] species ''Donax variabilis'' show diverse coloration and patterning in their phenotypes.]]
 
[[Image:Coquina variation3.jpg|thumb|right|260px|Individuals in the [[Mollusca|mollusk]] species ''Donax variabilis'' show diverse coloration and patterning in their phenotypes.]]
  
'''Phenotype''' is the total observable physical traits of an individual (organism or cell). Mayr (2001) notes that these observable features include [[anatomy|anatomical]], [[physiology|physiological]], [[biochemistry|biochemical]], and [[behavior|behavioral]] characteristics, in both a developing and developed individual. The term can also be used in reference to one particular trait or characteristic                                                                                                                                               that is measurable and is expressed in only a subset of individuals within that populations (Brenner and Miller 2002).
+
'''Phenotype''' is the total observable physical traits of an individual (organism or cell). Mayr (2001) notes that these observable features include [[anatomy|anatomical]], [[physiology|physiological]], [[biochemistry|biochemical]], and [[behavior|behavioral]] characteristics. The term can also be used in reference to one particular trait or characteristic that is measurable and is expressed in only a subset of individuals within that populations (Brenner and Miller 2002). For example, blue eye color, aggressive behavior, bilaterial symmetry, and length of antennae are phenotypic traits.
  
Brenner and Miller (2002) more specifically define a phenotype as a measurable trait
+
The phenotype of a developing or developed organism is held to be the result of interaction between the inherited [[genotype]] (the genetic makeup of the individual), transmitted epigenetic factors, and non-hereditary environmental variation. Some phenotypes are controlled entirely by the individual's [[gene|genes]]. Others are controlled by genes but are significantly affected by nongenetic or environmental factors. Still other phenotypes are entirely nongenetic, for example, a person's language or physical traits that were altered by surgery.
  
of an individual [[organism]] describes one of its [[trait (biology)|traits]] or characteristics that is measurable and that is expressed in only a subset of the individuals within that population <ref>Encyclopedia of Genetics, Ed. Sydney Brenner and Jeffrey H. Miller. San Diego: Academic Press, 2002.</ref>. Examples include
+
[[classical genetics|Geneticists]] use easily observable phenotypes to deduce an organism's genotype, and analyse complex phenotypes to help hypothesize about how individual genes function.
"blue eyes", or "aggressive behavior". Some phenotypes are controlled entirely by the individual's [[gene|genes]]. Others are controlled by genes but are significantly affected by nongenetic or environmental factors. Still other phenotypes are entirely nongenetic, for example, a person's language or physical traits that were altered by surgery.  
 
  
The phenotype is the result of interaction between the genotype and the environment."
+
==Genotype and phenotype==
 
+
The terms "genotype" and "phenotype" were created by Wilhelm Johannsen in 1911.
observable physical or biochemical characteristics of an organism as determined by both genetic makeup and envionrmnetal ifluect
 
  
observalbe characterists of an organism, such as shape color, bhaviro,
+
A '''genotype''' is the genetic makeup (set of [[gene]]s) of an individual organism or [[cell (biology)|cell]]. Genes are the units of [[inheritance|heredity]] in living organisms and are encoded in the organism's genetic material&mdash;those segments of [[DNA]] that cells transcribe into [[RNA]] and translate, at least in part, into [[protein]]s.
  
 +
An organism's genotype is a major (the largest by far for [[morphology]]) influencing factor in the development of its phenotype, but it is not the only one. For many traits, the genotype may set the potential and limits for phenotypic expression, but environmental influences can be major.
  
 +
Although there has been an historical debate regarding the prominence that should be given to "nature" (genes) versus "nuture" (environment), the consensus is that most characteristics of an organism are affected by both factors (Mayr 2001). For example, the presence or absence of nutrients will affect plant growth and health. The phrase ''norm of reaction'' refers to the amplitude of variation of a phenotype produced under different enviromental conditions (Mayr 2001).
  
 +
Many phenotypes also are determined by multiple [[gene]]s. Thus, the identity of one or a few [[allele]]s of an organism does not always enable prediction of its phenotype.
  
Many phenotypes are determined by multiple [[gene]]s and can also be influenced by [[natural environment|environmental]] factors. Thus, the identity of one or a few [[allele]]s of an organism does not always enable prediction of its phenotype.
+
Even two organisms with identical genotypes normally differ in their phenotypes. One experiences this in everyday life with monozygous (i.e. identical) twins.  Identical twins share the same genotype, since their genomes are identical; but they never have the same phenotype, although their phenotypes may be very similar.  This is apparent in the fact that their mothers and close friends can tell them apart, even though others might not be able to see the subtle differences. Furthermore, identical twins can be distinguished by their [[fingerprint]]s, which are never completely identical. Of course, personality differences can be substantial.
  
[[classical genetics|Geneticists]] use easily observable phenotypes to deduce an organism's genotype, and analyse complex phenotypes to help hypothesize about how individual genes function.
+
The concept of ''phenotypic plasticity'' describes the degree to which an organism's phenotype is determined by its genotype. A high level of plasticity means that environmental factors have a strong influence on the particular phenotype that develops. If there is little plasticity, the phenotype of an organism can be reliably predicted from knowledge of the genotype, regardless of environmental peculiarities during development. An example of high plasticity can be observed in [[larva]]l [[newt]]s: when these larvae sense the presence of predators, such as [[dragonfly|dragonflies]], they develop larger heads and tails relative to their body size and display darker pigmentation (Buskirk and Schmidt 2000). Larvae with these traits have a higher chance of survival when exposed to the predators, but grow more slowly than other phenotypes.
 
 
==Genotype and phenotype==
 
An organism's genotype is a major (the largest by far for [[morphology]]) influencing factor in the development of its phenotype, but it is not the only one.  Even two organisms with identical genotypes normally differ in their phenotypes.  One experiences this in everyday life with [[identical twins|monozygous (i.e. identical) twins]].  Identical twins share the same genotype, since their genomes are identical; but they never have the same phenotype, although their phenotypes may be very similar.  This is apparent in the fact that their mothers and close friends can always tell them apart, even though others might not be able to see the subtle differences.  Further, identical twins can be distinguished by their [[fingerprint]]s, which are never completely identical.
 
 
 
The concept of [[phenotypic plasticity]] describes the degree to which an organism's phenotype is determined by its genotype. A high level of plasticity means that [[environmental factor]]s have a strong influence on the particular phenotype that develops. If there is little plasticity, the phenotype of an organism can be reliably predicted from knowledge of the genotype, regardless of [[natural environment|environment]]al peculiarities during development. An example of high plasticity can be observed in [[larva]]l [[newt]]s<sup>1</sup>: when these larvae sense the presence of [[predator]]s such as [[dragonfly|dragonflies]], they develop larger heads and tails relative to their body size and display darker [[pigmentation]]. Larvae with these traits have a higher chance of [[Survival skills|survival]] when exposed to the predators, but grow more slowly than other phenotypes.
 
 
 
In contrast to phenotypic plasticity, the concept of [[canalisation (genetics)|genetic canalization]] addresses the extent to which an organism's phenotype allows conclusions about its genotype.  A phenotype is said to be canalized if [[mutation]]s (changes in the genome) do not noticeably affect the physical properties of the organism.  This means that a canalized phenotype may form from a large variety of different genotypes, in which case it is not possible to exactly predict the genotype from knowledge of the phenotype (i.e. the genotype-phenotype map is not invertible).  If canalization is not present, small changes in the genome have an immediate effect on the phenotype that develops.
 
 
 
The terms "genotype" and "phenotype" were created by [[Wilhelm Johannsen]] in 1911.
 
  
 +
In contrast to phenotypic plasticity, the concept of ''genetic canalization'' addresses the extent to which an organism's phenotype allows conclusions about its genotype. A phenotype is said to be canalized if [[mutation]]s (changes in the genome) do not noticeably affect the physical properties of the organism. This means that a canalized phenotype may form from a large variety of different genotypes, in which case it is not possible to exactly predict the genotype from knowledge of the phenotype (i.e. the genotype-phenotype map is not invertible).  If canalization is not present, small changes in the genome have an immediate effect on the phenotype that develops.
  
 
==Phenotypic variation==
 
==Phenotypic variation==
  
Phenotypic variation (due to underlying heritable [[genetic variation]]) is a fundamental prerequisite for [[evolution]] by [[natural selection]]. The [[fitness (biology)|fitness]] of an organism is a high-level phenotype determined by the contributions of thousands of more specific phenotypes. Without phenotypic variation, individual organisms would all have the same fitness, and changes in phenotypic frequency would proceed without any selection (randomly).
+
Phenotypic variation (due to underlying heritable genetic variation) is a fundamental prerequisite for a population's adaptation to its environment due to [[natural selection]]. The "fitness" of an organism is a high-level phenotype determined by the contributions of thousands of more specific phenotypes. Without phenotypic variation, individual organisms would all have the same fitness, and changes in phenotypic frequency would proceed without any selection (randomly).
  
 
The interaction between genotype and phenotype has often been conceptualized by the following relationship:
 
The interaction between genotype and phenotype has often been conceptualized by the following relationship:
Line 44: Line 37:
 
:'''genotype + environment + random-variation → phenotype'''
 
:'''genotype + environment + random-variation → phenotype'''
  
An example of the importance of random variation in phenotypic expression is [[Drosophila]] flies in which number of eyes may vary (randomly) between left and right sides in a single individual as much as they do between different genotypes overall, or between [[cloning|clones]] raised in different environments.
+
An example of the importance of random variation in phenotypic expression is ''[[Drosophila]]'' flies in which number of eyes may vary (randomly) between left and right sides in a single individual as much as they do between different genotypes overall, or between [[cloning|clones]] raised in different environments.
 
 
A phenotype is any detectable characteristic of an organism (i.e., structural, biochemical, physiological and behavioral) determined by an interaction between its genotype and environment (see [[genotype-phenotype distinction]] and [[phenotypic plasticity]] for a further elaboration of this distinction).
 
 
 
According to the [[autopoiesis|autopoietic]] notion of living systems by [[Humberto Maturana]], the phenotype is epigenetically being constructed throughout [[ontogeny]], and we as observers make the distinctions that define any particular trait at any particular state of the organism's life cycle.
 
  
The idea of the phenotype has been generalized by [[Richard Dawkins]] (in ''[[The Extended Phenotype]]'') to mean all the effects a gene has on the outside world which may influence its chances of being replicated. These can be effects on the organism in which the gene resides, the environment or other organisms.  
+
A phenotype is any detectable characteristic of an organism (i.e., structural, biochemical, physiological, and behavioral) determined by an interaction between its genotype and environment. According to the [[autopoiesis|autopoietic]] notion of living systems by [[Humberto Maturana]], the phenotype is epigenetically being constructed throughout [[ontogeny]], and we as observers make the distinctions that define any particular trait at any particular state of the organism's [[life cycle]].
  
The concept of phenotype can be extended to variations below the level of the gene that effect an organism's fitness. For example, [[silent mutations]] that do not change the corresponding amino acid sequence of a gene may change the frequency of [[guanine]]-[[cytosine]] base pairs ([[GC content]]). These base pairs have a higher thermal stability ("melting point", see also [[DNA-DNA hybridization]]) than [[adenine]]-[[thymine]], a property that might convey, among organisms living in high temperature environments, a selective advantage on variants enriched in GC content.
+
The concept of phenotype can be extended to variations below the level of the [[gene]] that effect an organism's fitness. For example, silent [[mutation]]s that do not change the corresponding [[amino acid]] sequence of a gene may change the frequency of [[guanine]]-[[cytosine]] base pairs (GC content). These base pairs may have a higher thermal stability ("melting point"]]) than [[adenine]]-[[thymine]], a property that might convey, among organisms living in high temperature environments, a selective advantage on variants enriched in GC content.
  
 
==References==
 
==References==
<references/>
+
* Brenner, S., and J. H. Miller (Eds.). 2002. ''Encyclopedia of Genetics''. San Diego: Academic Press. ISBN 0122270800.
 +
* Mayr, E. 2001. ''What Evolution Is''. New York: Basic Books. ISBN 0465044255.
 +
* Van Buskirk, J., and B. R. Schmidt. 2000. Predator-induced phenotypic plasticity in larval newts: Trade-offs, selection, and variation in nature. ''Ecology'' 81: 3009-3028.
  
{{genarch}}
 
  
 
{{credit|Phenotype|134231059|Genotype-phenotype_distinction|133072930}}
 
{{credit|Phenotype|134231059|Genotype-phenotype_distinction|133072930}}

Revision as of 20:49, 3 June 2007

Individuals in the mollusk species Donax variabilis show diverse coloration and patterning in their phenotypes.

Phenotype is the total observable physical traits of an individual (organism or cell). Mayr (2001) notes that these observable features include anatomical, physiological, biochemical, and behavioral characteristics. The term can also be used in reference to one particular trait or characteristic that is measurable and is expressed in only a subset of individuals within that populations (Brenner and Miller 2002). For example, blue eye color, aggressive behavior, bilaterial symmetry, and length of antennae are phenotypic traits.

The phenotype of a developing or developed organism is held to be the result of interaction between the inherited genotype (the genetic makeup of the individual), transmitted epigenetic factors, and non-hereditary environmental variation. Some phenotypes are controlled entirely by the individual's genes. Others are controlled by genes but are significantly affected by nongenetic or environmental factors. Still other phenotypes are entirely nongenetic, for example, a person's language or physical traits that were altered by surgery.

Geneticists use easily observable phenotypes to deduce an organism's genotype, and analyse complex phenotypes to help hypothesize about how individual genes function.

Genotype and phenotype

The terms "genotype" and "phenotype" were created by Wilhelm Johannsen in 1911.

A genotype is the genetic makeup (set of genes) of an individual organism or cell. Genes are the units of heredity in living organisms and are encoded in the organism's genetic material—those segments of DNA that cells transcribe into RNA and translate, at least in part, into proteins.

An organism's genotype is a major (the largest by far for morphology) influencing factor in the development of its phenotype, but it is not the only one. For many traits, the genotype may set the potential and limits for phenotypic expression, but environmental influences can be major.

Although there has been an historical debate regarding the prominence that should be given to "nature" (genes) versus "nuture" (environment), the consensus is that most characteristics of an organism are affected by both factors (Mayr 2001). For example, the presence or absence of nutrients will affect plant growth and health. The phrase norm of reaction refers to the amplitude of variation of a phenotype produced under different enviromental conditions (Mayr 2001).

Many phenotypes also are determined by multiple genes. Thus, the identity of one or a few alleles of an organism does not always enable prediction of its phenotype.

Even two organisms with identical genotypes normally differ in their phenotypes. One experiences this in everyday life with monozygous (i.e. identical) twins. Identical twins share the same genotype, since their genomes are identical; but they never have the same phenotype, although their phenotypes may be very similar. This is apparent in the fact that their mothers and close friends can tell them apart, even though others might not be able to see the subtle differences. Furthermore, identical twins can be distinguished by their fingerprints, which are never completely identical. Of course, personality differences can be substantial.

The concept of phenotypic plasticity describes the degree to which an organism's phenotype is determined by its genotype. A high level of plasticity means that environmental factors have a strong influence on the particular phenotype that develops. If there is little plasticity, the phenotype of an organism can be reliably predicted from knowledge of the genotype, regardless of environmental peculiarities during development. An example of high plasticity can be observed in larval newts: when these larvae sense the presence of predators, such as dragonflies, they develop larger heads and tails relative to their body size and display darker pigmentation (Buskirk and Schmidt 2000). Larvae with these traits have a higher chance of survival when exposed to the predators, but grow more slowly than other phenotypes.

In contrast to phenotypic plasticity, the concept of genetic canalization addresses the extent to which an organism's phenotype allows conclusions about its genotype. A phenotype is said to be canalized if mutations (changes in the genome) do not noticeably affect the physical properties of the organism. This means that a canalized phenotype may form from a large variety of different genotypes, in which case it is not possible to exactly predict the genotype from knowledge of the phenotype (i.e. the genotype-phenotype map is not invertible). If canalization is not present, small changes in the genome have an immediate effect on the phenotype that develops.

Phenotypic variation

Phenotypic variation (due to underlying heritable genetic variation) is a fundamental prerequisite for a population's adaptation to its environment due to natural selection. The "fitness" of an organism is a high-level phenotype determined by the contributions of thousands of more specific phenotypes. Without phenotypic variation, individual organisms would all have the same fitness, and changes in phenotypic frequency would proceed without any selection (randomly).

The interaction between genotype and phenotype has often been conceptualized by the following relationship:

genotype + environment → phenotype

A slightly more nuanced version of the relationships is:

genotype + environment + random-variation → phenotype

An example of the importance of random variation in phenotypic expression is Drosophila flies in which number of eyes may vary (randomly) between left and right sides in a single individual as much as they do between different genotypes overall, or between clones raised in different environments.

A phenotype is any detectable characteristic of an organism (i.e., structural, biochemical, physiological, and behavioral) determined by an interaction between its genotype and environment. According to the autopoietic notion of living systems by Humberto Maturana, the phenotype is epigenetically being constructed throughout ontogeny, and we as observers make the distinctions that define any particular trait at any particular state of the organism's life cycle.

The concept of phenotype can be extended to variations below the level of the gene that effect an organism's fitness. For example, silent mutations that do not change the corresponding amino acid sequence of a gene may change the frequency of guanine-cytosine base pairs (GC content). These base pairs may have a higher thermal stability ("melting point"]]) than adenine-thymine, a property that might convey, among organisms living in high temperature environments, a selective advantage on variants enriched in GC content.

References
ISBN links support NWE through referral fees

  • Brenner, S., and J. H. Miller (Eds.). 2002. Encyclopedia of Genetics. San Diego: Academic Press. ISBN 0122270800.
  • Mayr, E. 2001. What Evolution Is. New York: Basic Books. ISBN 0465044255.
  • Van Buskirk, J., and B. R. Schmidt. 2000. Predator-induced phenotypic plasticity in larval newts: Trade-offs, selection, and variation in nature. Ecology 81: 3009-3028.


Credits

New World Encyclopedia writers and editors rewrote and completed the Wikipedia article in accordance with New World Encyclopedia standards. This article abides by terms of the Creative Commons CC-by-sa 3.0 License (CC-by-sa), which may be used and disseminated with proper attribution. Credit is due under the terms of this license that can reference both the New World Encyclopedia contributors and the selfless volunteer contributors of the Wikimedia Foundation. To cite this article click here for a list of acceptable citing formats.The history of earlier contributions by wikipedians is accessible to researchers here:

The history of this article since it was imported to New World Encyclopedia:

Note: Some restrictions may apply to use of individual images which are separately licensed.